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Pharmacotherapy of Diabetes

Jae K. Shin R.Ph 323- 810- 3360

1. Biguanides(세포문 열어주는 보조제)

  • Metformin (Glucophage, Glucophage XR®®)
  • Primarily decreases hepatic glucose production and also increases peripheral insulin sensitivity. (Opens the door of cells so glucose can be utilize better)
  • 1st line agent in most patients
  • No hypoglycemia risk
  • Monitor diarrhea and abdominal cramping. It can be reduced by taking with food)

2. 2nd Generation Sulfonylureas(인슈린 생성 촉진제,주약)

  • Glimepiride(Amaryl®)
  • Glipizide (Glucotrol®, Glucotrol XL®)
  • Glyburide (Diabeta®, Micronase®)
  • Micronized glyburide (Glynase®)
  • Stimulates insulin secretion from the pancreas
  • 2nd line agent
  • Risk of Hypoglycemia is very common
  • Any agent should be taken before meals

3. Combination of Biaguanides and 2nd generation Sulfonylureas

  • Glipizide/Metformin (Metaglip®)
  • Glyburide/Metformin Glucovanc®)

4. a-glucosidase inhibitors(소화를 억제시켜 혈당 천천히 오르게)

  • Acarbose (Precose®)
  • Miglitol (Glyset®)
  • Prevent digestion of Carbohydrates

5. Thiazolidinediones(인슈린 활성 시키는약)

  • Pioglitazone (Actos®)
  • Pioglitazone/Metformin (ActosPlusMet®)
  • Primarily increase insulin sensitivity. Also decreases hepatic glucose output

6. Meglitinide(인슈린 생성촉진제, 단시간형)

  • Repaglinide (Prandin®)
  • Nateglinde (Starlix®)
  • Increase insulin secretion from pancreas

7. Amylin Mimetics(주사제)

  • Pramlintide (Symlin®)
  • Slows down the movement of food through the intestine. This slows down the absorption of glucose from the intestine, which reduces sudden increases in blood glucose.

8. Insulin Delivertives(인슈린 주사)

  1. Regular(humulin, novolin)
  2. NPH
  3. 70/30(N+R)
  4. 50+50(N+R)
  5. Lispro (100 Units/ml Humalog):10ml Bottle, 3ml X 5 Kwikpen
  6. Lispro(200 Units/ml Humalog): 3ml X 5 Kwikpen
  7. 75/25(lispro protamin +Humalog)
  8. 50+50(lisipro protamin +Humalog)
  9. Aspart(Novolog)
  10. 70/30(Aspart protamine+Novolog)
  11. Glulisine(Apidra)
  12. Glargine(100 Units/ml, Lantus) 10ml bottle, 3.0 ml X5 pen type SoloStar
  13. Glargine(300 Units/ml, Toujeo) 1.5 ml X 5 pen type SoloStar
  14. Detemir(Levemir)

9. GLP-1 AG(incretin Mimetic)(인크레틴 자연성분 또는 합성제제 주사이며 인슈린 주사는 아님)

  • Exenatide (Byetta®)
  • Exenatide ER (Byduron®)
  • Liraglutide (Victoza®)
  • Dulaglutide(Trulicity*)
  • Albiglutide(Tanzeum*)
  • (Liraglutide(Saxenda*)—only approved Obesity control
  • Increases insulin and decrease glucagon when glucose levels are elevated, increases satiety

10. DPP-IV Inhibitors(인크레틴 호르몬 분해효소 차단제, 여러기능을 도와주는 보조제)

  • Sitaglipitin (Januvia®)
  • Sitagliptin/Metformin (Janumet®)
  • Saxgliptin(Trajenta*)
  • Saxgliptin/Metformin(Jentadueto*)
  • linagliptin (Onglyza®)
  • alogliptin (Nesina®)
  • alogliptin/metformin(Kazano*)
  • slogliptin/pioglitazon(Oseni*)
  • Prevents incretin breakdown

11. SLGT-2(신장에서 당분의 재흡수를 막는 약)

  • Canagliflozin (Invokana®)
  • Canagliflozin/Metformin(Invokamet)
  • Dapagliflozin(Farxiga*), Dapagliflozin/Metformin(Xigduo XR)
  • Empagliflozin(Jandiance*), Empagliflozin/Metformin(Synjardy)
  • Empagliflozin/linagliptin(Glyzambi*)
  • Reduces renal glucose reabsorption and increasing urinary excretion of glucose

12. Inhailed Insulin(흡입 인슈린): Afrezza(human insulin powder) 4,8, 12 unit/ea short acting

Lantana Pharmacy :
300 N. Lantana St., #36, Camarillo, CA 93010 | 805-388-5888 | www.a1c7.com